Diagnostic Test Directory

Virology Laboratory

Epstein-Barr Virus (EBV) serology panel - serum specimen

  • LIS Mnemonic: IEBV

    Collect

    Gold (SST - Clot activator & gel)

    Volume Required

    2 ml blood

    Minimum Required

    1 ml serum

    Transport

    Room temperature

    Processing

    If multiple viral serologies are being requested from the same specimen, the general rule is to collect a total of 2-4 ml of blood for every 2-3 tests ordered. If sending specimens as an outside client, remove the serum from the clotted blood before transporting to the laboratory. The serum should be refrigerated after collection and transported to the laboratory at refrigerated temperatures (4°C). If an extended delay in transport of specimens is anticipated, rapidly freeze the specimens to at least -60°C and transport to the laboratory on dry ice. A single serum specimen is required for EBV antibody testing.

Days Performed

Monday, Wednesday, and Friday

Reported

Same day

Reflex Testing

N/A

CPT

86663,86664,86665

Methodology

Immunofluorescence. The panel of tests includes titration of IgG and IgM antibodies to the Viral Capsid Antigen (VCA), IgG antibodies to Diffuse (D) and Restricted (R) Early Antigens (EA), and IgG antibodies to Nuclear Antigens (EBNA) of EBV.

Interpretation

In most patients with acute EBV infection, high titers of both IgG and IgM to EBV viral capsid antigen (VCA) are detectable. Measurable IgG to VCA th

Reference Values

VCA (Viral Capsid Antigen) IgG <1:40 (not detected) VCA (Viral Capsid Antigen) IgM <1:10 (not d

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