Diagnostic Test Directory

Virology Laboratory

Hepatitis A virus (HAV) IgM antibody - serum or plasma specimen

  • Synonyms: Anti-HAV IgM, HAV IgM, Hepatitis A Virus IgM antibody
  • LIS Mnemonic: HAVIGM

    Collect

    PREFERRED: Serum is the preferred specimen. Collect blood in a 4 ml Gold Serum Separator Tube-Clot Activator & Gel. REMARK: Plasma is an acceptable alternative specimen. Blood can be collected in p

    Volume Required

    4 ml of blood

    Minimum Required

    2 ml of blood

    Transport

    A total of 2-4 ml of blood (for every 2-3 Hepatitis and HIV tests ordered) should be collected. For the CHOP enterprise, submit blood specimens as soon as possible at room temperature to Central Laboratory Services. For outside clients, it is recommended that serum or plasma specimens be removed from the clot, red blood cells, or separator gel as soon as possible after collection and before shipping specimens. When shipping serum or plasma specimens, package and label specimens in complian

    Stability

    Serum or plasma specimens should be stored for no longer than 3 days at room temperature or 7 days at 2-8C following specimen collection and separation from clot, red blood cells, or separator gel. If

    Unacceptable conditions

    Do not use serum or plasma specimens that are heat-inactivated, pooled, grossly hemolyzed, or contain obvious microbial contamination. Performance has not been established for the use of cadeveric specimens or the use of boody fluids other than human serum or plasma.

    Specimen Handling

    Unprocessed blood specimens should routinely be refrigerated at 4C upon arrival in the laboratory. O

Days Performed

Monday thru Friday

Reported

Daily

CPT

86709

Methodology

Chemiluminescent microparticle immunoassay (CMIA)

Disease Information

Utility:

Indicator of recent acute infection with Hepatitis A virus (HAV). IgM-specific antibody to HAV is present from the onset of symptoms and declines to nondetectable levels within 3-6 months in most individuals. Low levels of anti-HAV IgM may persist for more than 1 year in some patients.

Interpretation

S/CO < 0.80 NONREACTIVE - Anti-HAV IgM not detected. Does not exclude the possibility of exposure to or infection with HAV. Levels of anti-HAV IgM m

Reference Values

S/CO < 0.80 NONREACTIVE for IgM antibody to hepatitis A virus.

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