Diagnostic Test Directory

Virology Laboratory

Hepatitis A virus (HAV) IgG antibody - serum specimen

  • Synonyms: Anti-HAV IgG, HAV IgG antibody
  • LIS Mnemonic: HAVIGG

    Collect

    PREFERRED: Serum is the specimen of choice. Collect blood in a 4 ml Gold Serum Separator Tube-Clot Activator & Gel. REMARK: Plasma IS NOT an acceptable alternative specimen for HAV IgG antibody tes

    Volume Required

    4 ml of blood

    Minimum Required

    2 ml of blood

    Transport

    A total of 2-4 ml of blood (for every 2-3 Hepatitis and HIV tests ordered) should be collected. For the CHOP enterprise, submit blood specimens as soon as possible at room temperature to Central Laboratory Services. For outside clients, it is recommended that sera be removed from the clot, red blood cells, or separator gel as soon as possible after collection and before shipping specimens. When shipping serum specimens, package and label specimens in compliance with applicable state, feder

    Stability

    Serum specimens should be stored for no longer than 3 days at room temperature or 7 days at 2-8C following specimen collection and separation from clot, red blood cells, or separator gel. If a storage

    Unacceptable conditions

    Do not use serum specimens that are heat-inactivated, pooled, grossly hemolyzed, or contain obvious microbial contamination. Performance has not been established for the use of cadeveric specimens or the use of boody fluids other than human serum.

    Specimen Handling

    Unprocessed blood specimens should routinely be refrigerated at 4C upon arrival in the laboratory. O

Days Performed

Monday thru Friday

Reported

Daily

CPT

86790

Methodology

Chemiluminescent microparticle immunoassay (CMIA)

Disease Information

Utility:

This assay measures IgG-specific antibody responses to hepatitis A virus (HAV) infection. Anti-HAV IgG antibody is an indicator of recent or past infection with hepatitis A virus or seroconversion following immunization. If recent (acute) HAV infection is suspected, also order the hepatitis A virus (HAV) IgM antibody test. Testing of serum for anti-HAV IgG is used to determine the immune status of an individual, to assess a person's risk for traveling to an endemic region or working in a high-risk area, and to assist in making decisions to administer HAV vaccine or immune globulin prophylaxis following exposure to HAV. This assay has not been FDA cleared or approved for the screening of blood or plasma donors.

Interpretation

S/CO < 1.00 NONREACTIVE - No detection of HAV IgG antibodies. S/CO > or = 1.00 REACTIVE - Anti-HAV IgG antibodies detected. After an acute infec

Reference Values

S/CO < 1.00 NONREACTIVE for anti-HAV IgG antibodies.

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